Bi amp biwire

I have a pair of r28f 150 rms 600 max watts that are bi amp or biwireable. What would be better and or not recommended. Currently just using my sonance 2120t amp 120watts per channel . Im also in possession of sonance 260 ,60watts per channel at 2 channel's for 3 rooms. Three sets of 2 channels. Could I put 2 sets going to the bass and 1 to the high frequency ? Maybe just the channel from no 2120t for low end and a single 60 watts from the 260. What would be safest. Am open to the best route to take what ever it may be. Thanks in advance.

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